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Table 4 Baseline values for lean and non-lean NAFLD patients between LSM < 8 kPa and LSM ≥ 8 kPa groups

From: Clinical characteristics of lean and non-lean non-alcoholic fatty liver disease: a cross-sectional study

 

Lean

Non-lean

LSM < 8 kPa

LSM ≥ 8 kPa

t/ × 2/Z

P

LSM < 8 kPa

LSM ≥ 8 kPa

t/ × 2/Z

P

N (male/female)

869 (449/420)

47 (25/22)

0.041

0.839

9691 (7349, 2342)

970 (768, 202)

5.421

0.02

Age

52 (42, 59)

50.67 ± 11.636

− 1.599

0.11

50 (41, 57)

53 (44, 60)

− 7.866

 < 0.001

Hb, g/L

143 (133, 154)

143.17 ± 14.952

− 0.083

0.934

152 (141, 159)

154 (144, 162)

− 4.985

 < 0.001

PLT, × 109/L

231 (195.5, 270)

234.37 ± 58.217

− 3.393

0.001

230 (196, 267)

223 (181, 262)

− 4.727

 < 0.001

TP, g/L

73.487 ± 4.277

73.487 ± 4.276

− 0.952

0.342

73.1 (70.4, 76.1)

74.1 (71, 77.2)

− 6.005

 < 0.001

ALB, g/L

47.278 ± 2.752

47.278 ± 2.752

1.1

0.272

47.1 (45.3, 48.9)

47 (45, 48.9)

− 1.02

0.308

GLB, g/L

26.1 (23.8, 28.5)

26.3 (23.8, 29.9)

− 1.231

0.218

26 (23.8, 28.4)

27 (24.8, 29.5)

− 7.934

 < 0.001

TB, μmol/L

13.2 (10.8, 17)

12.2 (9.4, 16.3)

− 1.364

0.172

13.4 (10.7, 17)

13.8 (10.975, 17.3)

− 2.203

0.028

CB, μmol/L

4 (3, 5.25)

4.404 ± 1.98

− 0.295

0.768

4.2 (3.2, 5.4)

4.4 (3.4, 5.7)

− 3.404

0.001

ALT, U/L

21 (16, 31)

25 (19, 40)

− 2.684

0.007

27 (20, 40)

39 (26, 65)

− 17.07

 < 0.001

AST, U/L

23 (19, 28)

27 (22, 35)

− 3.642

 < 0.001

24 (21, 30)

31 (24, 41)

− 19.059

 < 0.001

GGT, U/L

21 (15,32)

33 (20, 58)

− 4.226

 < 0.001

28 (19, 44)

38.5 (26, 61)

− 13.652

 < 0.001

ALP, U/L

69 (58, 83)

71.77 ± 21.182

− 2.643

0.008

69 (58, 82)

73 (61, 87)

− 6.569

 < 0.001

TG, mmol/L

1.37 (0.96, 2.065)

1.53 (1.15, 2.58)

− 1.991

0.046

1.65 (1.16, 2.46)

1.9 (1.34, 2.923)

− 7.633

 < 0.001

TC, mmol/L

5.04 (4.425, 5.75)

5.1319 ± 0.983

− 1.182

0.237

5.07 (4.46, 5.69)

5.07 (4.45, 5.8)

− 1.129

0.259

HDL-C, mmol/L

1.33 (1.12, 1.57)

1.3732 ± 0.353

− 1.457

0.145

1.18 (1.01, 1.39)

1.11 (0.96, 1.3)

− 7.409

 < 0.001

LDL-C, mmol/L

2.98 (2.46, 3.55)

3.041 ± 0.813

− 1.872

0.061

3.05 (2.54, 3.57)

3.07 (2.54, 3.64)

− 0.637

0.524

BUN, mmol/L

4.76 (4, 5.506)

4.879 ± 1.191

− 0.845

0.398

4.92 (4.18, 5.78)

4.96 (4.16, 5.843)

− 0.834

0.405

Cr, μmol/L

65.4 (56.85, 76.95)

67.133 ± 14.189

− 0.616

0.538

73 (62.9, 82)

73 (62.675, 81.6)

− 0.243

0.808

UA, μmol/L

321.2 (267.8, 393.05)

335.756 ± 91.291

− 2.311

0.021

379.4 (316.9, 443.9)

394.7 (334.3, 464.075)

− 5.428

 < 0.001

FBG, mmol/L

4.94 (4.605, 5.34)

5.11 (4.61, 5.8)

− 1.48

0.139

5.04 (4.7, 5.5)

5.395 (4.86, 6.2)

− 12.017

 < 0.001

BMI, kg/m2

22.2 (21.6, 22.6)

22.1 (21.6, 22.7)

− 0.422

0.673

26.3 (24.9, 28)

27.6 (25.8, 30.1)

− 14.689

 < 0.001

HbA1c, %

5.4 (5.2, 5.7)

5.5 (5.2, 5.9)

− 1.432

0.152

5.5 (5.3, 5.8)

5.7 (5.4, 6.2)

− 11.077

 < 0.001

CAP, db/m

254 (247, 261)

255 (245, 270)

− 0.336

0.737

270 (253, 287)

287 (268, 306)

− 17.777

 < 0.001

LSM, kPa

5.5 (4.7, 6.2)

9.8 (8.4, 12)

− 11.564

 < 0.001

5.5 (4.8, 6.3)

9.7 (8.6, 11.6)

− 51.444

 < 0.001

TyG

8.588 (8.239, 9.044)

8.919 ± 0.752

− 2.253

0.024

8.822 (8.448, 9.264)

9.054 (8.63, 9.51)

− 10.257

 < 0.001

TyG-BMI

190.837 ± 15.517

191.922 (183.589, 201.599)

− 0.985

0.325

232.708 (215.63, 253.549)

252.492 (228.37, 279.66)

− 17.01

 < 0.001

TG/HDL-C

1.033 (0.649, 1.698)

1.271 (0.775, 2.114)

− 2.068

0.039

1.404 (0.885, 2.295)

1.728 (1.091, 2.948)

− 8.667

 < 0.001

FIB-4

1.063 (0.787, 1.482)

1.355 (1.027, 2.07)

− 3.776

 < 0.001

1.011 (0.737, 1.353)

1.206 (0.858, 1.694)

− 10.956

 < 0.001

APRI

0.247 (0.194, 0.331)

0.368 (0.26, 0.5)

− 4.838

 < 0.001

0.275 (0.213, 0.355)

0.355 (0.263, 0.518)

− 18.002

 < 0.001

AST/ALT

1.053 (0.822, 1.333)

1 (0.819, 1.333)

− 0.713

0.476

0.875 (0.692, 1.118)

0.771 (0.621, 1)

− 9.413

 < 0.001

  1. Defined LSM ≥ 8 kPa as liver fibrosis not excluded group
  2. Continuous variables were shown as mean ± SD or median (interquartile range), and categorical variables were expressed as counts (percentage)
  3. Hb hemoglobin, PLT platelet, TP total protein, ALB albumin, GLB globulin, ALT alanine aminotransferase, AST aspartate aminotransferase, TB total bilirubin, DB direct bilirubin, GGT gamma-glutamyl transpeptidase, ALP alkaline phosphatase, Cr creatinine, BUN blood urea nitrogen, UA Uric Acid, FBG fasting blood glucose, TG triglyceride, CHOL cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1c glycosylated hemoglobin, TyG triglyceride and glucose index, TyG-BMI triglyceride glucose-body mass index, FIB-4 fibrosis-4 score, APRI aspartate aminotransferase to platelet ratio index, CAP controlled attenuation parameter, LSM liver stiffness measurement
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Nutrition & Metabolism

ISSN: 1743-7075

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