Fig. 4
From: Taurine corrects lupus CD4+ T cell imbalance through inhibition of mTORC1 signaling
Taurine helped restore CD4+ T cell balance. (A-E) Splenocytes from acetone-treated control B6 mice, R848-treated B6 mice and taurine treated R848 lupus mice, the percentages of T helper 1 (Th1), T helper 17 (Th17), T helper 2 (Th2), regulator T (Treg), T follicular helper (Tfh) cells. (F-K) Splenocytes from acetone-treated control B6 mice, R848-treated B6 mice were stimulated with anti-CD3/CD28 antibodies and taurine for 24 h, comparison of the proportion of ROS (ROS production), Ki-67 (cell proliferation), CD69 (cell activation), Annexin V+ 7AAD+ (cell apoptosis), SPiDER-βGal and P21 cells (cell senescence) in splenic CD4+ T cells of the three groups. p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001