Fig. 5
From: Taurine corrects lupus CD4+ T cell imbalance through inhibition of mTORC1 signaling
Taurine regulated CD4+ T cells through the mTORC1 pathway. (A) Splenocytes from acetone-treated control B6 mice, R848-treated B6 mice were stimulated with anti-CD3/CD28 antibodies and taurine for 24 h, then analyzed for phosphorylation of indicated proteins. Graphs show mean fluorescence intensities of p-S6, p-AKT in CD4+ and CD8+ T cells. (B) The percentages of CD4+ T cells of acetone-treated control B6 mice, R848-treated B6 mice cultured with taurine and with or without MHY1485 for 24 h. (C) The percentages of ROS, Ki-67, SPiDER-βGal, P21 and Treg in CD4+ T cells of of acetone-treated control B6 mice, R848-treated B6 mice cultured with taurine and with or without MHY1485 for 24 h. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001